Skin sympathetic nerve activity and nocturnal septal ST-segment elevation

Hyperadrenergic postural orthostatic tachycardia syndrome (hPOTS) is a subgroup of postural orthostatic tachycardia syndrome with prominent sympathetic activation symptoms. We recently recorded skin sympathetic nerve activity (SKNA) in ambulatory participants with hPOTS at baseline and after being treated with clonidine.1 We performed a secondary analysis to determine whether reduced average SKNA (aSKNA) during sleep was associated with ST-segment elevation. Key Findings: There is a negative correlation between average skin sympathetic nerve activity (aSKNA) and the septal ST-segment height; there is a higher septal ST segment and lower aSKNA when asleep compared with awake; reduced aSKNA at night is associated with nocturnal ST-segment elevation.