Utility of salivary gland biopsy in diagnosing Sjogren's syndrome in a POTS patient population

POTS patients undergo labial salivary gland biopsies (LSGB) for histologic confirmation of Sjogren's syndrome (SS). Predictive features of positive results are unknown. 161 POTS patients underwent LSGB. Their charts were reviewed for antibody and diagnostic testing results. Only 11% (17/161) of POTS patients were SS positive. There were more positive ANA antibodies in those with positive LSGB (65% v 28%, p = .0026). Positive skin nerve biopsy for small fiber neuropathy (SFN) was associated with positive LSGB (p = .046). A positive ANA and skin biopsy for SFN are two helpful features in selecting POTS patients for LSGB.